Answer: The short answer is no. As minoxidil without propylene glycol should be equivalently effective as minoxidil with propylene glycol. Both glycerin and propylene glycol are pharmacologically inactive ingredients in the minoxidil products. They are used in minoxidil solutions because (1) they are humectants, i.e. they help to moisturize the skin and help protect from the drying effect of the alcohol; (2) they increase and stabilize the solubility of minoxidil; and (3) they keep a small quantity of minoxidil on the surface of the scalp to allow for continued absorption after the alcohol necessary to the base solution has penetrated.
The 5% and higher minoxidil solutions and lotions have the potential to promote regrowth of more hair and thicker hair, but they do not change the genetic properties of the hair follicles. Although the growth (anagen) phase may be lengthened, the dormant (telogen) phase of approximately 100 days is unchanged. In order to [...]